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filingDate 2017-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c10b2acb389ac5f42aef21716a75f752
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publicationDate 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11519021-B2
titleOfInvention Methods of identifying microsatellite instability
abstract The present invention relates to methods and kits for identifying microsatellite instability (MSI) in a sample. In particular it relates to identifying microsatellite instability in a tumor sample, which may be from a subject suspected of having colorectal cancer or Lynch syndrome. The methods and kits can be used to identify mismatch repair defects. More particularly the invention relates to a panel of markers for a sequencing based MSI test, that can differentiate between MSI-H and MSS CRCs. The invention also allows for determination of biological significance, differentiating between PCR and sequencing errors and MSI induced indels/mutations.
priorityDate 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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