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filingDate 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1180b2b168e1f0cc0580d372303d2ba1
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publicationDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11497768-B2
titleOfInvention Antigen-binding protein that recognizes MAGE-A4-derived peptide
abstract CAR-T cells for cancer therapy are provided with an antibody that recognizes the MAGE-A4-derived-peptide/HLA-A2 complex. The antibody includes the VH amino acid sequence of SEQ ID NO: 36 and the VL amino acid sequence of SEQ ID NO: 38. The antibody preferably is provided with the amino acid sequence of SEQ ID NO: 32. Such CAR-T cells can be used in CAR infusion therapy in which a cancer-specific intracellular antigen is used.
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