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filingDate 2016-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11497733-B2
titleOfInvention Combination therapy of HSP90 inhibitors and PD-1 inhibitors for treating cancer
abstract A pharmaceutical composition comprising a PD-1 inhibitor and a Hsp90 inhibitor, or a tautomer, or a pharmaceutically acceptable salt thereof, wherein the Hsp90 inhibitor is 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-methyl-indol-5-yl)-5-hydroxy-[1,2,4] triazole or 5-hydroxy-4-(5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-1,2,4-triazol-3-yl)-2-isopropylphenyl dihydrogen phosphate. Also provided is a method for treating cancer in a subject in need thereof, using the pharmaceutical composition described herein.
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