http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459356-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_063cf63dc8e22e4b61e163da89706816 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2021-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a38300d8b181b5861af14337e81e3fc5 |
| publicationDate | 2022-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11459356-B2 |
| titleOfInvention | Neuronal nicotinic acetylcholine receptor-targeting polypeptide and use thereof |
| abstract | A neuronal nicotinic acetylcholine receptor-targeting polypeptide and the use thereof are disclosed. The polypeptide has an amino acid sequence of SEQ ID NO:1, and includes four cysteine residues, Cys2, Cys3, Cys7, and Cys13, that can form two disulfide bonds. Molecular docking simulation illustrated its capacity to target a and a subunits of nAChR and the stable structure of resultant nAChR_BP-nAChR complex. In addition, effect of the polypeptide on calcium response of nAChR-overexpressing CN21 cells revealed that the polypeptide was capable of significantly inhibiting nAChRs. Accordingly, the nAChR-targeting polypeptide nAChR_BP is a promising nAChR-targeting drug. |
| priorityDate | 2021-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.