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filingDate 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11440992-B2
titleOfInvention Oxime cross-linked biocompatible polymer hydrogels and methods of use thereof
abstract Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
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