http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11419955-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_238a0cbb4d846151b3a4844bad7f9879 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-587 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1244 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12 |
| filingDate | 2019-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a47cb590eb0c7cf06ea8f04e99d529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d47959e8376d33c487756f7775ae80c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff80925ddaf87b9767baab163c696ce5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95072cc49ff2e10c85ce6550ecb80cf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbc38bebaa1a5da0ac1c5708e3880bcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_813236abd83a76cfbdc82e30aea077f3 |
| publicationDate | 2022-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11419955-B2 |
| titleOfInvention | Multimodal silica-based nanoparticles |
| abstract | The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11744897-B2 |
| priorityDate | 2009-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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