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filingDate 2017-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11415551-B2
titleOfInvention Resonator for detecting single molecule binding
abstract Various embodiments of an apparatus for measuring binding kinetics of an interaction of an analyte material present in a fluid sample are disclosed. The apparatus includes a sensing resonator having at least one binding site for the analyte material; actuation circuitry adapted to drive the sensing resonator into an oscillating motion; measurement circuitry coupled to the sensing resonator and adapted to measure an output signal of the sensing resonator representing resonance characteristics of the oscillating motion of the sensing resonator; and a controller coupled to the actuation and measurement circuitry, wherein the controller is adapted to detect an individual binding event between the at least one binding site and a molecule of the analyte material.
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