| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b2a1431d2febd8a4f17a340e7a4d310
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f278ab8fb471c7f78279bde9b4eda8a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32eabb54fa477c5973a7e6aa4e54213a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb768fd318bbebeb520f5d6d2e09960c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40cba4c51bee95d448284106754726a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8c98218b5b1f62c9d456a045771793b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-29 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y201-01137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-72 |
| filingDate |
2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99c26fbe5bf38a5cfe3cc24e1cd527cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ab44e4767bf0a974236d2b7653112ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1c1d45ba56fa5a3bec92b6fcf14ffb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bea2029fe5631e233db65e88b8dc38e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df2f9c89d58754c35066045f1922664e |
| publicationDate |
2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11396520-B2 |
| titleOfInvention |
Synthesis of the organoarsenical antibiotic arsinothricin and derivatives thereof |
| abstract |
The subject invention provides methods and procedures for synthesis and/or semi-synthesis of the novel antibiotic arsinothricin (AST) and derivatives. Arsinothricin (AST), a new broad-spectrum organoarsenical antibiotic, is a non-proteinogenic analog of glutamate that effectively inhibits glutamine synthetase. The subject invention provides chemical synthesis of an intermediate in the pathway of AST synthesis, hydroxyarsinothricin (AST-OH), which can be converted to AST by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. The methods provide a source of the novel antibiotic that will be required for future clinical trials. The subject invention also provides AST derivatives as a new class of antibiotics. |
| priorityDate |
2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |