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filingDate 2021-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3541e8c78ba0947614f1e2a6ff5af0b
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publicationDate 2022-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11338032-B2
titleOfInvention Methods of preparing anti-human papillomavirus antigen T cells
abstract Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
priorityDate 2013-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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