| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2005-14296
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3303
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4839
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-725
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-1723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-369 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-369
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H20-13 |
| filingDate |
2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4803ddf3df43bc880bda0cddd309799
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41f9f8e831c3f4fabfff30db18824eca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08ba53844cf19115bea86b4ed0284a83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a6d30fe4cef216de9becb79c57df733 |
| publicationDate |
2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11266780-B2 |
| titleOfInvention |
Methods and systems for closed-loop control of drug administration |
| abstract |
A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug. |
| priorityDate |
2015-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |