| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81ba2c4156354c844d4a8883be561f00 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-003 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
| filingDate |
2017-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c829cf0f7059ad7a6c1a2a93a87d3304
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4453046c0751f15146353b01798161d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fcee78f2f64382040f8a6bdd2998a2f |
| publicationDate |
2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11208669-B2 |
| titleOfInvention |
Lentivirus packaging system comprising a synthetic positive feedback loop |
| abstract |
Novel lentivirus packaging systems engineered with a synthetic gene network having a positive feedback loop to amplify the expression of virus genes are provided. When co-transfected into a host cell with a transfer plasmid and envelope vector, extremely high viral titers are achieved when compared to transfection of a host cell with conventional third generation packaging systems. Methods for enhancing production of lentivirus, compositions comprising high titer lentivirus, and therapeutic methods based on delivery of lentiviral nucleic acid to target cells are also provided. |
| priorityDate |
2016-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |