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filingDate 2017-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_474ffe213a8a23d478110db74240ad14
publicationDate 2021-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11161905-B2
titleOfInvention Recombinant antibodies to programmed death 1 (PD-1) and uses thereof
abstract Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.
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