| abstract |
Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia. n Specifically provided is a macrocyclic polypeptide represented by formula (I) n n[wherein A is selected from the linking groups A 1 to A 6 ; X aa1 is a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent; X aa2 is a residue of an aromatic amino acid or a neutral amino acid; X aa3 is a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid; X aa4 is Ser, Thr, Ala, or m S; X aa5 is Gly or Ser; X aa6 is a residue of a basic amino acid or a neutral amino acid; X aa7 is a residue of a neutral amino acid or an acidic amino acid; X aa8 is a residue of an aromatic amino acid; X aa9 is a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid; X aa10 is a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid; X aa11 is a residue of an aromatic amino acid; and X aa12 is a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof. |