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filingDate 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f6af6d4bcd164bea14a7cf624b11e16
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publicationDate 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11118161-B2
titleOfInvention Method for direct transdifferentiation reprogramming into neurons using electromagnetic-induced metal nanoparticles
abstract The present invention relates to a method for direct transdifferentiation into neurons using metal nanoparticles magnetized by an electromagnetic field, and to a cell therapeutic agent for the treatment of cerebral nerve diseases, comprising neurons differentiated by the method. In the present invention, it was specifically verified that the direct transdifferentiation efficiency into neurons can be remarkably improved through the above method and the symptoms of cerebral nerve diseases, such as a stroke, can be effectively alleviated. Therefore, in the treatment of degenerative cerebral nerve diseases, the target therapy is expected to be implemented through a more fundamental approach.
priorityDate 2015-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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