http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11105819-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d48332d6787b06b2e9e9ea8250682d7a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2560-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-107497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-28 |
| filingDate | 2020-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac3194d50cf39e6eeacd2deb71c05cd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8118c4fbb1a6c85323e92370f17c0512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72092b081b593c206801c2f55dcf5101 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9917a141adec31382ad9bb0bbf74a2b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5614080762c5fe85cbe1ab53e625ee10 |
| publicationDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11105819-B2 |
| titleOfInvention | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| abstract | Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides. |
| priorityDate | 2008-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 202.