| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55bc2bae9f65cfaede67b62128f00e9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21aee5b5527ac8eb29d5a785f1fb19b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-073 |
| filingDate |
2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_418b0836bce7415d68e8330ac5519ca6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebb0554e98010c048ada0d320d0bbc4b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d5d059be8f6c675cb89410e45810a33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_169a011c443dff8d06f461715259f58f |
| publicationDate |
2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11104699-B2 |
| titleOfInvention |
Phosphorous protecting groups and methods of preparation and use thereof |
| abstract |
Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein. |
| priorityDate |
2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |