| abstract |
A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (V L ) and a heavy chain variable domain (V H ), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed. |