| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_087bed7abab91ae0f927879f9fe8b273 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2540-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-543 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F132-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-1825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2208
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2291
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-226
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2273 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-22 |
| filingDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1b2c7748aa6e80d7cabf4c285c39893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_560f9cd65c24448b898bf0af6ebeabe3 |
| publicationDate |
2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11053209-B2 |
| titleOfInvention |
Highly efficient synthesis of z-macrocycles using stereoretentive, ruthenium-based metathesis catalysts |
| abstract |
A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at −20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z). |
| priorityDate |
2017-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |