| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b053f71e1ef16d91a9786d77203fd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef71626b7f444cf050d8913fe489df74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc7bd9cf43465263fdd8a9e2f1ac1483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4610436ad6a6889e5998ce2e3e5df1e9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6037 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0275 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate |
2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16871cf14aef4629c577c11848363777
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83ffaf4f541e2163f029c1ae18f83b16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04fd6081e5adf153a8828db909e29353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59de69cbe6662674ff9853bc5aafab3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b67102c0d8c73ee1592757c2777586e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b80c10b75aaf52eeebb79eab7f51d96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f42821937282915a893e27209c59212e |
| publicationDate |
2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11052142-B2 |
| titleOfInvention |
Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| abstract |
For the first time individual (free from impurities of penta- and hexa-acetylated derivatives) di-, tri- and tetra-acetylated S-LPS of endotoxic bacteria and combinations thereof were obtained and their immunobiological, physical-chemical and chemical-pharmaceutical properties were studied. n For the first time the principal possibility of their clinical application was directly demonstrated as vaccines and pharmaceutical compositions containing the modified S-LPS individual as monocomponent or combinations thereof as two and three component active substance, respectively. n The modified S-LPS and combinations thereof have high safety profile and provide low pyrogenicity and high immunogenicity. Developed on their basis vaccines and pharmaceutical compositions demonstrate anti-shock activity, high efficiency and specificity, broad-spectrum action and also good chemical-pharmaceutical parameters. |
| priorityDate |
2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |