http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11041843-B2

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8299f96f332437e70034f159a0b2b06
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-4161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48714
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
filingDate 2018-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cd69a56e62dad10ddab9f00697dcce6
publicationDate 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11041843-B2
titleOfInvention Organic toroidal array apparatus of making for direct and reagent-free sensing of the endotoxin activities of a single E. coli cell
abstract The invented organic memristor/memcapacitor device comprises arrayed cross-bar donut-shape toroidal matrix self-assembling membrane on an electrode mimicking mitochondria's double membrane surface structure and the direct electron-relay function, that used to mimic functions of Fibroblast Growth Factor Receptor 1 (FGFR1) and choline acetyltransferase (CHAT), which enables bio-communication signals flowing directly between the endotoxin interacted membrane electrode assembly (MEA) working electrode and a cathodic electrode; and from a biomarker Acetyl coenzyme A (AcCoA) interacted the MEA electrode and the cathodic electrode when applied a definite potential, respectively, for detection of a single E. coli cell and detection of a picomolar concentration of AcCoA under nature enzyme-free, antibody-free and reagent-free conditions. The sensor offers multiple functions for monitoring neuronal synapse pulse energy output. The robust analytical performances of the device for monitoring endotoxins in milk are important in the dairy industry.
priorityDate 2016-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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