| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate |
2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b93ca348c191c3a65191fae40247fc26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ef0e843e867ffdb12a4e01a199a0390
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f239d5c1e0cc74e6e5b354f57b581405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b11ff961cf5e13fc8167b583ce490317
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afda08e5030fd77c825466f4401c5c2d |
| publicationDate |
2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11008322-B1 |
| titleOfInvention |
Method of synthesizing (1S,12bS) lactam ester compound |
| abstract |
Disclosed herein is a method of synthesizing a (1S,12bS) lactam ester compound, including: subjecting a dihydrocarboline diester compound of formula (II) to asymmetric hydrogenation and lactamization in an organic solvent in the presence of an iridium catalyst precursor, a chiral diphosphine ligand and a halogen-containing reagent under hydrogen atmosphere to produce the (1S,12bS) lactam ester compound of formula (I), as shown in the following reaction scheme, where R 1 , R 2 and R 3 are defined in the same manner with the specification. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113321643-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113321643-B |
| priorityDate |
2020-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |