| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a02f9198a942f100aedf6c2ed9aa36c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdaa64756184e715af6cb25ebc318917 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2827 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2020-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4683aeb5f34b737e6279896b0a8f30c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b542cced184ffc8a080f6bb016b5400e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9aa5d87bb2562222ffe1ba8bcecd1c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30ece7a968d1b13153838e9021372992
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b83a46483f5cff93b48094fad0918868
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f52245ebc99dafed10321651f129f86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afac7d9862da1d1fbce8f67bf9b42b8f |
| publicationDate |
2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10995141-B2 |
| titleOfInvention |
Modified anti-PD-L1 antibody and methods and uses for treating a neurodegenerative disease |
| abstract |
The present specification discloses modified anti-PD-L1 antibodies that abolishes Fc-related effector function and enhances clearance rate while maintaining therapeutic efficacy for neurodegenerative disease modification. The present specification also discloses nucleic acid sequences and expression constructs encoding such modified anti-PD-L1 antibodies as well as methods of making such modified anti-PD-L1 antibodies. In addition, the present specification discloses methods of treatment and uses that employ an administration regime of the disclosed anti-PD-L1 antibodies that ensures the antibodies are present for only a specific period of time and then are sufficiently cleared from the body to ensure treatment efficacy is maintained. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021221888-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021188977-A1 |
| priorityDate |
2019-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |