| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7d7f51b30ceeb9e2e0d55b74908ec06 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0453 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate |
2017-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c72376e11b24475530b98e10d185607
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3b7d02e3aacce1a40c6ad8cdc42f971
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcd91c963548dc7a30706937066f732f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef6d6cb2ef4f24cc9f1049789cab07ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb42eeba1150548dc31867442897a940 |
| publicationDate |
2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10981913-B2 |
| titleOfInvention |
11C -labeled 06 -benzylguanine, pet probe capable of visualizing 06-methyl guanine methyl-transferase activity, and production method of the same |
| abstract |
An object of the invention is to provide a 11 C-labeled O 6 -benzylguanine capable of obtaining a PET image and a process for producing the same. n The 11 C-labeled O 6 -benzylguanine of the invention is represented by the following chemical formula (a). n nThe 11 C-labeled O 6 -benzylguanine is produced by: a coupling step of cross-coupling a methyl iodide labeled with 11 C and the following organotin compound (b) (R 1 represents an alkyl group, and R 2 and R 3 represent a leaving group which can be eliminated with a base) in the presence of a palladium complex, a phosphine ligand, and cuprous halide in an aprotic lactam; and a desorption step of desorbing the leaving groups R 2 and R 3 of the coupling product obtained by the coupling step with a base. |
| priorityDate |
2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |