| abstract |
Disclosed herein are compounds of formula (I) n nand pharmaceutically acceptable salt thereof, wherein variables X, R 1 , R 2 , and R 3 are defined herein. These compounds are potent modulators of human TNFα activity and, accordingly, of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |