http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10961194-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ee97713ba9fe3dc0a60ef3b73e9491a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_884a96dc21c42fc594b58fd05e966483 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 |
| filingDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8843448382e066e8b72928c07fd113fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48fa0b97342d51d6a6d8c74566b64f32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bfd8a2810c90d3073e9921923a4d3da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2599f1b420f36ec5ee772ba99ec2920f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f28e98604352ca20077a53e675a8f6d |
| publicationDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10961194-B2 |
| titleOfInvention | Method for purifying ropinirole hydrochloride |
| abstract | Provided is a method for purifying ropinirole hydrochloride (4-2-di-n-propylaminoethyl-1,3-dihydro-2H-indole-2-ketohydrochloride). The method comprises: adding ropinirole hydrochloride containing a monopropyl impurity A into water, adding organic solvent, stirring and dissolving at room temperature, adding alkali, stirring, standing, demixing, and removing an aqueous layer; optionally, drying the organic layer by using anhydrous magnesium sulfate, and filtering; and adding acyl chloride or acid anhydride into the organic layer, stirring, concentrating the organic layer to be dry, adding an organic solvent into the obtained oily matter, adding concentrated hydrochloric acid, and stirring, so as to obtain the ropinirole hydrochloride. By using the method, the impurity A in the ropinirole hydrochloride can be effectively removed, and the ropinirole hydrochloride can be obtained with a high yield and a high purity, so that the impurity A is controlled and the purity of the product reaches a medicinal standard. |
| priorityDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.