| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42d3020ad67c717f34d32e1448c74281 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1284723adf48bc0ab908e75807325c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3f1eaa328d7b8bb1a1e412756740c3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61e2c4cd82ae6b1fdb96b4a7a284bc8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20fa5104989340a2beb7c1b70b867c6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b60ef96b7911f559c5834d2e68a18b25 |
| publicationDate |
2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10955407-B2 |
| titleOfInvention |
In vitro toxicity screening assay |
| abstract |
The invention relates to methods for predicting the in vivo toxicity of oligonucleotides, such as antisense oligonucleotides using in vitro cell based assays based on gymnotically administering oligonucleotides to primary mammalian hepatocytes and subsequently measuring the levels of toxicity biomarkers such as the release of LDH into the cell culture media and/or intracellular ATP. |
| priorityDate |
2015-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |