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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_693888771b93eca48282727f21ce1555
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publicationDate 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10952973-B2
titleOfInvention Production method of pregabalin-containing composition and pregabalin-containing composition
abstract Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:n (1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.
priorityDate 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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