http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10937550-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e757fd4fedc4fe825bb81b1b466a0947 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B10-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H50-50 |
| filingDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8804c8b8500bbe5a496f6260599ffd7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78bc76174d207b267ae4e8dc71e70930 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e782dc1bc138fddbfb9c2d85290162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd91eca04c0b77a132492b3bbd9d600b |
| publicationDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10937550-B2 |
| titleOfInvention | Phylogenetic tumor evolution trees with distribution of variants in cell populations |
| abstract | A computer-implemented method includes inputting, to a processor, an N×K SSV frequency matrix M and an error tolerance δ≥0, wherein N is a number of SSVs and K is a number of time points, wherein matrix M comprises a plurality of time-resolved mutation frequencies for each SSV; clustering, by the processor, matrix rows in M that satisfy the δ to provide a plurality of SSV clusters; assigning, by the processor, a mean cluster frequency to each SSV within each SSV cluster; calculating errors for removing low frequency rows, for rounding rows to 1 or 0; assigning a root node for all SSV clusters of frequency 1; and calculating, by the processor, a δ-compliant time-series evolution tree with error ≤δ comprising the root node and a plurality time-stratified nodes, wherein calculating includes assigning a clonal configuration, optionally re-configuring the clonal configuration, and calculating error for re-configuring. |
| priorityDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 378.