| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3edb9aa141cda1fdc8cb548d0c57f59c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0627
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-0681
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-0693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-0065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48707
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7793 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N15-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01L3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N15-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-076 |
| filingDate |
2016-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2620e98577932deb92ce6afdf02ae435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc4029a756f255eb518691da15d296de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd746c1a2f677ba20eac2d41f6f0510f |
| publicationDate |
2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10852298-B2 |
| titleOfInvention |
Devices and methods for quantification of male fertility |
| abstract |
Disclosed herein is a low cost and rapid microfluidic based method and test device for quantifying male fertility potential. The device can simultaneously measure three critical semen parameters rapidly, namely live sperm concentration, motile sperm concentration, and sperm motility. The device includes a transparent substrate and a top sheet with two holes therethrough and an intermediate sheet sandwiched between the substrate and the top sheet. The wells formed by holes form a concentration measuring well (C) and a motility well (M) formed by the top sheet with these two holes bonded to the intermediate sheet. A colorimetric agent is located on the top surface of the intermediate sheet at the bottom of each well which changes color when in contact with sperm. In the motility well a porous membrane is located on top of the colorimetric agent and a liquid buffer may be placed on the top surface of the porous membrane. Applying part of a sperm sample to the C well results in direct contact of any live sperm with the colorimetric agent causing a color change, applying part of the sperm sample to the M well results in live sperm with sufficient motility to swim vertically down through the liquid buffer and through the porous membrane to the colorimetric agent. Evaluating the intensities of the color change of the colorimetric agents before and after contact with the sample gives a measure of total concentration of live sperm and motile sperm from which sperm motility is calculated. |
| priorityDate |
2015-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |