http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10837020-B2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54b76ad39dd30db901041bcb171f21a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_624ddb1066e92a6c21328e1eb965eea3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8381805eba6d034fc77bd230dd02e6e2 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 |
filingDate | 2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2020-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbd3c9ea62428b228d9450061441bbe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89c144075cc9c01b9a1e82248074c6a8 |
publicationDate | 2020-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-10837020-B2 |
titleOfInvention | Innate immune suppression enables repeated delivery of long RNA molecules |
abstract | The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts. |
priorityDate | 2009-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1528.