| abstract |
The invention provides compounds of the formula: n n n n n n n n n n n n R 1 is OR 11 , or NR 5 R 5′ ; n R 2 is H or F; n R 5 is H, C 1 -C 6 alkyl, OH, C(═O)R 6 , O(C═O)R 6 or O(C═O)OR 6 ; n R 5′ is H or C 1 -C 6 alkyl; n R 6 is C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; n R 13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R 22 ;n nand the other variables are as defined in the claims,n nwhich are of use in the treatment of cancer, and related aspects. |