http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793512-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_410f0501615b939917d4bd25c155e317 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-56 |
| filingDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b266a1e9cedaa4e5f423c1438acec56b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eba5822ccf29ecb65c90b1b5a9bd3ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_759b963d7e5aaf6eb0d1a99ff1a22fa3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cb4d3442604304d47900975ce17deaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53a4b8903d5d9588f410e56e8e6e984f |
| publicationDate | 2020-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10793512-B2 |
| titleOfInvention | Preparation method for high purity racemic adrenaline |
| abstract | Disclosed is a preparation method for a racemic adrenaline as represented by formula II. The method comprises the following steps: compound 1 is directly racemized in an acidic solution to produce compound 2, the acid solution comprising neither sodium bisulfite nor salicylic acid; and specifically comprises (a), in the acid solution of which the pH is 0.5-1.5, compound 1 is placed under the protection of nitrogen gas and, with the reaction temperature being controlled at 75-95° C., stirred and reacted for 1-3 hours; (b) the reaction solution is controlled at a temperature of 5-20° C., into which an activated carbon is added, under the protection of nitrogen gas, stirred for 20-40 minutes, and filtered, then a filtrate is collected; the filtrate is controlled at a temperature of 5-20° C., the pH thereof is adjusted using ammonia to 8.5-9.5, and is filtered when the pH is stabilized, and a filter cake is washed and dried to produce a high purity racemic adrenaline white powder. The weight yield of the product produced per the preparation method of the present invention is greater than 90%, the chromatographic purity is greater than 96%, and the ee value approaches zero; the invention is inexpensive, simple to operate, favors industrialized production, and has a broad application prospect. |
| priorityDate | 2018-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.