| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_366759959a879950036c4e69dc8fd483 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-232
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-236
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-128
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-148 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 |
| filingDate |
2017-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf7190dc9f2da1fa6599fe3ca0293986
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_874f213bc1dac0a89a0f7aaed7bf5ed8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d03875388b15694e965be52ee3485f67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6ae444e6b8611954ca96ff603eb7aed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec84e29ee08f15fd277f0141fba6e047 |
| publicationDate |
2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10729821-B1 |
| titleOfInvention |
Method for preparing chitosan/heparinized graphene oxide composite multilayer film on surface of medical magnesium alloy |
| abstract |
A method for preparing a chitosan/heparinized graphene oxide composite multilayer film on the surface of a medical magnesium alloy comprises the following steps: firstly preparing negatively charged heparinized graphene oxide; then performing surface chemical treatment and self-assembly of 16-phosphonohexadecanoic acid molecules on the medical magnesium alloy; further covalently immobilizing chitosan on the surface of the magnesium alloy, thereby constructing a positively charged material surface; finally, alternately immersing the surface-modified magnesium alloy material in heparinized graphene oxide and a chitosan solution, and then fully adsorbing, and obtaining the chitosan/heparinized graphene oxide composite multilayer film after drying. The surface modification of the medical magnesium alloy by adopting the method of the present invention can significantly improve the corrosion resistance and biocompatibility of the magnesium alloy to lay a foundation for the application of the magnesium alloy in the field of implantable medical devices such as vascular stents. |
| priorityDate |
2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |