| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate |
2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_437ebaa6dbff3b3b1b2c9e536765fc36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e421a40bb6560bfd11074ed78df15353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_716540fff72b06c90202aeda5139a3b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdcdd22dfba0cf8429f92925bff17de |
| publicationDate |
2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10704105-B2 |
| titleOfInvention |
Mutations of the PIK3CA gene in human cancers |
| abstract |
Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the PI3K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286531-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773440-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180803-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11453913-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459611-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11525163-B2 |
| priorityDate |
2004-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |