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filingDate 2016-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_921f360c7f9e59a37618a545688a5db9
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publicationDate 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10702552-B2
titleOfInvention SiRNA of human IL-6 and recombinant expression CAR-T vector and their construction methods and applications
abstract Provided are a siRNA of the human interleukin 6, a recombinant expression CAR-T vector, and a construction method and a use thereof. The siRNA can be used in the treatment of acute B-cell lymphocytic leukemia with CAR19-T for eliminating or alleviating the symptoms of cytokine release syndrome (CRS), and can also be used for alleviating the CRS symptoms caused by treating tumours with CAR-T and even can also be used for alleviating CRS caused by other types of treatment.
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