| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a51af9318dda81d010950203b19bfe37 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D21-262
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D2009-0086 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-303
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-4055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D21-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D9-0054 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D21-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 |
| filingDate |
2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81313fae2cf4077dd6ff97a9c954d2fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d39d987a13f68031086c541b0a9fe643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54bcbba0002b6be7d94cbbc2a3598220
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cd03e9b3f681d19c7fd92b77cae0f5f |
| publicationDate |
2020-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10669535-B2 |
| titleOfInvention |
Methods for the isolation of extracellular vesicles and other bioparticles from urine and other biofluids |
| abstract |
Compositions and methods for the isolation of protein-nucleic acid complexes and microvesicles (collectively referred to as “bioparticles”) released by mammalian cells into body fluids or cell culture media are provided. Isolated bioparticles of the invention contain biological molecules that are useful as diagnostic/prognostic biomarkers or for identification of therapeutic targets (e.g., disease or disorder-associated miRNAs). The isolation of biological molecules as described herein results in purification and concentration of the molecules. Methods for producing bio fluids that are free of detectable bioparticles, that are largely depleted of bioparticles, or that possess a reduced concentration of bioparticles compared to a bio fluid starting material (collectively termed “bioparticle-depleted”) are also provided. Isolation of bioparticle-depleted biofluid is useful, e.g., in experimental systems where it is desirable to use a biofluid that does not contain endogenous bioparticles, or has been substantially depleted of endogenous bioparticles, from the source material. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021137999-A1 |
| priorityDate |
2014-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |