| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 |
| filingDate |
2017-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba6f60342570770b58cc6450812279d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4a4a73994f9caa0f20419839f207759
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e8e64f34d32e26dde073a632a4935fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73576632d836bf483e47351eae116f2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f7cbf014e1cc460e7e5cd718882f295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98ee41f27f6eb40884d2fcfc66d8a093
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e29c0bc8156512f21e3eb0e7cbb8106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c5ab5225230b2981b9d84ac19f385a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e415e28d8e01d5ded2fbe660b2f0fad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_629d21bf927f1daf1fc4afe5822de783 |
| publicationDate |
2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10662177-B2 |
| titleOfInvention |
Blocking toll-like receptor 9 signaling with small molecule antagonist |
| abstract |
The present invention relates to small molecule 4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defense for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation. |
| priorityDate |
2016-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |