| abstract |
A diphenylaminopyrimidine and triazine compound of Formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate or solvate thereof is disclosed n nIn formula I, A is C or N; X and Y are independently selected from hydrogen, halo, cyano, trifluoromethyl, alkoxy, alkyl, aryl, alkenyl, alkynyl and nitro; or X and Y, together with the atoms to which they are attached, form a phenyl or an heteroaromatic ring; R 1 isn n nR 2 is CD 3 or CD 2 CD 3 ; R 3 isn n nR 4 is hydrogen, methyl, trifluoromethyl, cyano or halo; R 5 is hydrogen, alkyl, substituted and unsubstituted phenyl, allyl or propargyl; R 6 and R 7 are independently selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl and propargyl; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heterocycloalkyl group. The compound has pharmacodynamic and pharmacokinetic properties and ALK kinase inhibitory activity. |