| abstract |
Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R 1 is an aliphatic linear or branched C 6 -C 10 acyl group, or (I′) R 5 is —CH(CH 3 ) 2 , —CH 2 CH(CH 3 ) 2 , —CH(CH 3 )CH 2 CH 3 , or —CH 2 C 6 H 5 ; R 6 is —CH(CH 3 ) 2 , —CH 2 CH(CH 3 ) 2 , or —CH(CH 3 )CH 2 CH 3 ; each of R 2 , R 3 , R 4 , R 7 and R 8 is either —(CH 2 ) x CH 2 NH 2 or —(CH 2 ) x CH 2 N(CH 2 SO 3 M) 2 ; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R 2 , R 3 , R 4 , R 7 and R 8 are —(CH 2 ) x CH 2 N(CH 2 SO 3 M) 2 . |