| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3819
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3828
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J39-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J39-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J39-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J39-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 |
| filingDate |
2015-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e9db69d6564d6eda28b0b17d610ae4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aba7862a2d14f0418f3037b9afed5d94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3709d78f965f2a2a47e24551fb9416d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_153224086409d90bd340911e2ba897f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9247877b86a8220813b997e3f608e3 |
| publicationDate |
2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10626142-B2 |
| titleOfInvention |
Purification platform for bispecific antibodies |
| abstract |
High resolution protein A chromatography employing a chaotropic agent and pH gradient or pH step elution buffer results in improved peak resolution between closely related molecular species. Bispecific antibodies containing a protein A-binding-ablating substitution CH3 domain paired with a protein A-binding CH3 domain are separated with high peak resolution from monospecific antibodies containing a protein A-binding-ablating substituted CH3 domain paired with the protein A-binding-ablating substituted CH3 domain and monospecific antibodies containing a protein A-binding CH3 domain paired with the protein A-binding CH3 domain. Useful chaotropic agents include magnesium chloride and calcium chloride. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11306135-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459374-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11104715-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11753459-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407813-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180540-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11505593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11505594-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548932-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11186625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11485770-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098112-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542317-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11732025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11174283-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299532-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11649273-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11535663-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11440950-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472861-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286290-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11053280-B2 |
| priorityDate |
2014-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |