Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
filingDate |
2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66a59bdf250e2a1f41b990209afe3043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44d13b67c8bf8067ab90b040a5148974 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c68ec7523e889135d2c18643a32a538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0b11324cf0ffb504bd0cadbaaa927ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee6bea62de427d78c15f4f903086628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dfe46d1b632bc94413194f086b1bc75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f08da6a0c06767407b972e7a073c451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64a3e934c9cc18dc3ee97c97f58c4e01 |
publicationDate |
2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10619217-B2 |
titleOfInvention |
Oligodendroglioma drive genes |
abstract |
Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes. |
priorityDate |
2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |