Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3edb9aa141cda1fdc8cb548d0c57f59c |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-12 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L89-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-34 |
filingDate |
2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43276c7776f473531dcf75eb8da00345 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b4578b5b24faaae99c51ec9d0c44e3e |
publicationDate |
2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10596301-B2 |
titleOfInvention |
Device including biological agents for in vitro induction of biomineralization |
abstract |
This disclosure provides a product comprised of a collagen gel to which recombinant human Amelotin (AMTN) protein is added. This AMTN-collagen gel is applied to one side of a physiologically acceptable scaffold that has first been impregnated with AMTN-free collagen gel. The resulting two-layer collagen membrane (layer 1 comprised of scaffold surrounded by collagen gel; layer 2 comprised of collagen gel containing AMTN) is applied to a mineralized tissue surface such as dentin and bone with the collagen gel containing AMTN of layer 2 facing this mineral surface. Upon immersion in simulated body fluid (SBF), the presence of AMTN in layer 2 triggers the formation of hydroxyapatite mineral deposits that intimately connect with the existing mineral surface and thus provide physical attachment. A similar product is disclosed but in addition to AMTN, it contains the Odontogenic, Ameloblast-Associated (ODAM) protein as well with both proteins exhibiting a synergistic effect. |
priorityDate |
2017-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |