| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C245-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-18 |
| filingDate |
2014-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac6ce4f9371e9ce9942e527a7e5bea0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d490401bc21691d2b6ac09f2e0801d54 |
| publicationDate |
2020-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10577303-B1 |
| titleOfInvention |
Reagents and methods for esterification |
| abstract |
A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: n nwherein the R 1 and R 2 groups of the diazo compound are selected such that the corresponding organic compound of formula:n n nexhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022157548-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022055979-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11091423-B2 |
| priorityDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |