| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14687eb1d34a9a00bd12725a2e42d611 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| filingDate |
2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128edcfb81fe388985361c06461b60b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c5f923aec8dba3d0db0fc82dd011ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27279140df140e91fc364408a2d35f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d1810ab414288ce82be96cca89cbbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_826988d5b02c219e0e722b5c12f4ca95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c69b2f56b0e5e3143c5c0243c02c762d |
| publicationDate |
2020-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10570132-B2 |
| titleOfInvention |
Process for preparing an intermediate for avibactam |
| abstract |
A method for preparing an intermediate for avibactam, and specifically relates to a method for preparing ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt (II). With 5R-[(benzyloxy) amino] piperidine-2S-carboxylate oxalate (III) as the raw material is reacted with the amide of Formula IV via amidation to prepare the compound of Formula V; the resulting compound of Formula V is reacted with the carbonylation reagent via urea cyclization to obtain the compound of Formula VI; the benzyl or the substituted benzyl in the compound of Formula VI is removed by catalytic hydrogeneration, then the resulting compound is sulfatated by sulfur trioxide complex and is salinized into tetrabutylammonium to obtain the final product (II). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11208417-B2 |
| priorityDate |
2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |