| abstract |
Provided herein is a compound of Formula I, or a salt thereof, n nwherein R 1 is a moiety having the following structure:n n nwherein Z is selected from the group consisting of O and N; X is selected from the group consisting of a bond, NH, and C(O)NH; and A is selected from the group consisting of substituted aryl and substituted heteroaryl. Compounds of Formula I are useful as opioid receptor agonists. Because the compounds exhibit relatively low levels of β-arrestin recruitment, they do not produce the negative side effects commonly associated with morphine-derived compounds. |