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filingDate 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb3bb7ba4bcf3b73c1b99dc7e9f15629
publicationDate 2020-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10551377-B2
titleOfInvention Quantification method of autoantibody
abstract A method of quantifying an autoantibody includes the steps of reacting a biological sample containing the autoantibody as a test substance with an antigen that is specifically recognized by and bound to the autoantibody, in competition with a known amount of a competition antibody that competes with the autoantibody for binding to the antigen; reacting the autoantibody bound to the antigen with a detection antibody that recognizes and binds to the autoantibody, but does not recognize the competition antibody; measuring a signal derived from the detection antibody bound to the autoantibody; and calculating an amount of the autoantibody contained in the biological sample by utilizing, as an index therefor, an amount of the competition antibody that provides 50% reduction of the signal derived from the detection antibody which is bound to the autoantibody in absence of the competition antibody.
priorityDate 2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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