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filingDate 2016-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10480023-B2
titleOfInvention Method for blocking miRNA
abstract A blocking nucleic acid for use in reducing the abundance of a non-target micro-RNA (miRNA) in an miRNA library is provided, including: a single-stranded complementary region at one of the 5′ end of the blocking nucleic acid or the 3′ end of the blocking nucleic acid, that anneals with a binding region at a first end of the unwanted miRNA; a hairpin loop forming region or other double-stranded region adjacent to the complimentary region, in which all of the terminal ends of the blocking nucleic acid except one are unavailable to participate in ligase reactions. Methods and kits for using the blocking nucleic acid are also provided.
priorityDate 2015-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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