| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c89c43f22924db342dfa6a24ed6032c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71cb8af727a7b275767014734e40db92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116546ef965d61144d9de8925103515c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-968
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-972 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6812
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 |
| filingDate |
2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e53949266b634bf471db010376c91b24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_391a7193c6f1bc30c5c89ab0135b7d6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bac26acb6c2016b19d1fe3fec607ee4 |
| publicationDate |
2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10444236-B2 |
| titleOfInvention |
Method of detection of proteolysis products in plasma and a diagnostic system for its application |
| abstract |
Immunological diagnostic methods that use the whole-length molecule of plasminogen or its peptide fragments as universal detectors of proteolysis products having a C-terminal lysine are proposed. The method of this immunological diagnostic is to identify the human diseases associated with increased activity of proteolytic enzymes. A diagnostic test system comprised of a detector—the full-length molecule and its presented peptide fragments—is disclosed. The technical result includes achieving the required degree of dissociation of the antigen-antibody complex in a sample from the subject, as well as changing the conformation of proteins using an incubation buffer containing organic solvents in the disclosed ratios, that can significantly increase the sensitivity of the method for determining the concentration of proteolytic fragments with a C-terminal lysine binding with plasminogen or fragments thereof. |
| priorityDate |
2015-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |