Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faf53b336355bb76e95f40b0acd5a339 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2562-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36031 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-389 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-0546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0488 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-6819 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-0488 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-053 |
filingDate |
2016-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_847fcbfd3766f81b9ecbf70f58f9ad00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26b01685c27f76859486c610117d29a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09f45b5d5878163392cd375bc26121ce |
publicationDate |
2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10426958-B2 |
titleOfInvention |
Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
abstract |
Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal. |
priorityDate |
2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |