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filingDate 2017-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10400031-B2
titleOfInvention Identification of antibodies specific for lyssaviruses and methods of their use
abstract Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.
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